Cultural value of architecture in homes and neighbourhoods

This paper provides an account of the Cultural Value of Architecture in Homes and Neighbourhoods, (CVoA), a project developed with the Royal Institute of British Architects (RIBA). The first stage of the project was a critical review of ‘grey literature’ since 2000, industry based research on the value of architecture subdivided into themes: overall value; health and wellbeing; neighbourhood cohesion and heritage and belonging. Findings from the review revealed a marked absence of evidence of the value of architecture and an over preoccupation with the final building, the product of an interdisciplinary team not just Architects, as well as a general confusion about what it is that Architects do. Further consultation has led to the development of a framework for defining and communicating the skillsets of Architects and for developing an evidence base for their value. Our target audience is non-Architects as we are concerned with making the profession more inclusive hence our desire to create simple definitions and terminology

A Feasibility Study on Image Inpainting for Non-cleft Lip Generation from Patients with Cleft Lip

A Cleft lip is a congenital abnormality requiring surgical repair by a specialist. The surgeon must have extensive experience and theoretical knowledge to perform surgery, and Artificial Intelligence (AI) method has been proposed to guide surgeons in improving surgical outcomes. If AI can be used to predict what a repaired cleft lip would look like, surgeons could use it as an adjunct to adjust their surgical technique and improve results. To explore the feasibility of this idea while protecting patient privacy, we propose a deep learning-based image inpainting method that is capable of covering a cleft lip and generating a lip and nose without a cleft. Our experiments are conducted on two real-world cleft lip datasets and are assessed by expert cleft lip surgeons to demonstrate the feasibility of the proposed method.Comment: 4 pages, 2 figures, BHI 202

Cultural Value of Architecture in Homes and Neighbourhoods

Little is known about the benefits of architectural expertise in the making of homes and neighbourhood. This project had two workpackages, the first a critical review of ‘grey literature’, the plethora of reports produced by industry, government, research councils and others to find evidence of value and of the way in which value has been collected. The findings from this workpackage have fed into the second a series of consultations with industry experts and interested parties culminating with a public consultation on the cultural value of architecture in the Sheffield University School of Architecture Liveworks. Together the workpackages provide the foundations for demonstrating the value of architectural expertise in this area. Architecture is rarely, if ever, mentioned in any of the 100 documents that we reviewed. The focus is instead on ‘design’, an unhelpfully vague term as anyone can ‘design’. We also found that attempts at demonstrating value generally focus on the finished product, building or place. As these are the result of an interdisciplinary team the value of the architect’s input is very hard to discern. Our primary recommendation is that any future frameworks of architectural value should focus on processes of architecture (verb not noun) and the benefits that architectural skillsets bring to a project, rather than on the final built product. This conclusion was endorsed through our work with marketing experts as we developed a strategy for selling the brand architect. It is difficult to sell architecture when there is such a general level of confusion about what it is. We have for this reason gone back to square one in developing a tool, an ‘I Spy Guide to Architecture’, to help non-architects understand and engage with the skills and values that have gone into creating their local built environment. To do this we have had to segment architectural practice into different value systems (commercial, cultural and social) and describe the skillsets within each. Only once the skillsets are defined can we begin to establish and promote their value

Number and timing of primary cleft lip and palate repair surgeries in England: whole nation study of electronic health records before and during the COVID-19 pandemic

Objective: To quantify differences in number and timing of first primary cleft lip and palate (CLP) repair procedures during the first year of the COVID-19 pandemic (1 April 2020 to 31 March 2021; 2020/2021) compared with the preceding year (1 April 2019 to 31 March 2020; 2019/2021)./ Design: National observational study of administrative hospital data./ Setting: National Health Service hospitals in England./ Study population: Children <5 years undergoing primary repair for an orofacial cleft Population Consensus and Surveys Classification of Interventions and Procedures-fourth revisions (OPCS-4) codes F031, F291)./ Main exposure: Procedure date (2020/2021 vs 2019/2020)./ Main outcomes: Numbers and timing (age in months) of first primary CLP procedures./ Results: 1716 CLP primary repair procedures were included in the analysis. In 2020/2021, 774 CLP procedures were carried out compared with 942 in 2019/2020, a reduction of 17.8% (95% CI 9.5% to 25.4%). The reduction varied over time in 2020/2021, with no surgeries at all during the first 2 months (April and May 2020). Compared with 2019/2020, first primary lip repair procedures performed in 2020/2021 were delayed by 1.6 months on average (95% CI 0.9 to 2.2 months). Delays in primary palate repairs were smaller on average but varied across the nine geographical regions./ Conclusion: There were significant reductions in the number and delays in timing of first primary CLP repair procedures in England during the first year of the pandemic, which may affect long-term outcomes

Cancer-selective, single agent chemoradiosensitising gold nanoparticles

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics

Neural predictive control of broiler chicken and pig growth

Active control of the growth of broiler chickens and pigs has potential benefits for farmers in terms of improved production efficiency, as well as for animal welfare in terms of improved leg health in broiler chickens. In this work, a differential recurrent neural network (DRNN) was identified from experimental data to represent animal growth using a nonlinear system identification algorithm. The DRNN model was then used as the internal model for nonlinear model predictive control (NMPC) to achieve a group of desired growth curves. The experimental results demonstrated that the DRNN model captured the underlying dynamics of the broiler and pig growth process reasonably well. The DRNN based NMPC was able to specify feed intakes in real time so that the broiler and pig weights accurately followed the desired growth curves ranging from to +12% and to +20% of the standard curve for broiler chickens and pigs, respectively. The overall mean relative error between the desired and achieved broiler or pig weight was 1.8% for the period from day 12 to day 51 and 10.5% for the period from week 5 to week 21, respectively

Polygenic basis and biomedical consequences of telomere length variation.

Funder: Health Data Research UK EU/EFPIA Innovative Medicines Initiative Joint Undertaking BigData@Heart (11607).Funder: Health Data Research UKTelomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized UK Biobank participants. We identified 197 independent sentinel variants associated with LTL at 138 genomic loci (108 new). Genetically determined differences in LTL were associated with multiple biological traits, ranging from height to bone marrow function, as well as several diseases spanning neoplastic, vascular and inflammatory pathologies. Finally, we estimated that, at the age of 40 years, people with an LTL >1 s.d. shorter than the population mean had a 2.5-year-lower life expectancy compared with the group with ≥1 s.d. longer LDL. Overall, we furnish new insights into the genetic regulation of LTL, reveal wide-ranging influences of LTL on physiological traits, diseases and longevity, and provide a powerful resource available to the global research community

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy